PHOTOLABILE LINKER FOR THE SOLID-PHASE SYNTHESIS OF BASE-SENSITIVE OLIGONUCLEOTIDES

Authors
DELLAQUILA C IMBACH JL RAYNER B
Citation
C. Dellaquila et al., PHOTOLABILE LINKER FOR THE SOLID-PHASE SYNTHESIS OF BASE-SENSITIVE OLIGONUCLEOTIDES, Tetrahedron letters, 38(30), 1997, pp. 5289-5292
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
30
Year of publication
1997
Pages
5289 - 5292
Database
ISI
SICI code
0040-4039(1997)38:30<5289:PLFTSS>2.0.ZU;2-6
Abstract
alpha-Nitrophenyl-1,3-propanediol was covalently linked to long chain alkyl amine controlled pore glass (LCAA-CPG) beads through a stable ph osphoramidate diester link. The resulting solid support was found suit able for the automated synthesis of 3'-phosphate unmodified as well as base-sensitive oligonucleotides. Efficient cleavage from the solid su pport was achieved by photolysis. (C) 1997 Elsevier Science Ltd.