Sinocranial aspergillosis: a form of central nervous system aspergillosis in South India

Of the 21 patients with aspergillosis of central nervrous system seen durin g the years 1990-1997, 16 (76%) had aspergillosis of sino-cranial origin. T he occupation in patients with sino-cranial aspergillosis was either agricu ltural or manual work and predisposing risk factors were present in only tw o (12.5%) patients. Skull-base syndromes were the presenting features in 13 patients and three patients presented with features of intracranial space- occupying lesion. Paranasal sinus mass lesions were seen in all the 16 pati ents. Computerized tomography showed intracranial extradural-enhancing mass lesions in the anterior, middle or posterior cranial fossa in nine (68%) p atients, intracranial and orbital lesions in four and orbital lesions in th ree. Well-formed granuloma with dense fibrosis was the histological feature . Survival rates were not good even after surgical and antifungal chemother apy. Surgical treatment was subradical in our series. The majority of cases of sinocranial aspergillosis are reported from countries with temperate cl imates and the high incidence in these regions is probably related to const ant exposure to the high spore content of pathogenic Aspergillus species in the 'mouldy' work environment.