Concentration of soluble adhesion molecules (sVCAM-1, sICAM-1 and sL-Selectin) in the cerebrospinal fluid and serum of patients with multiple sclerosis and systemic lupus erythematosus with central nervous involvement

Objectives: The aim of the present study was to investigate the role of sol uble adhesion molecules in the pathogenesis of multiple sclerosis (MS) and systemic lupus erythematosus (SLE) with demyelinating syndrome. Methods: Pa ired cerebrospinal fluid (CSF) and serum samples were analysed by an ELISA method to determine the concentrations of sVCAM-1, sICAM-1 and sL-selectin. Intrathecal syntheses of the adhesion molecules were calculated. Results: Elevated serum and CSF concentrations of sVCAM-1 were present in all patien t groups. Intrathecal synthesis of sVCAM-1 was present in the relapsing-rem itting and secondary progressive forms of MS. Intrathecal synthesis of sICA M-1 was observed in all clinical forms of MS. MS patients with progressive forms of the disease and SLE patients were characterised by intrathecal syn thesis of sL-selectin. Conclusions: The data presented suggest that (1) blo od-brain barrier damage can be assumed both in systemic disease and organ-s pecific disease (sVCAM-1), (2) clinical forms of MS differ from each other in respect to concentrations of adhesion molecules and (3) similar immunolo gical events in the central nervous system of SLE patients with demyelinati ng syndrome and progressive forms of MS can be assumed (sL-selectin). Copyr ight (C) 2001 S. Karger AG, Basel.