Increased serum levels of interleukin-18 in patients with multiple sclerosis

Authors
Nicoletti, F Di Marco, R Mangano, K Patti, F Reggio, E Nicoletti, A Bendtzen, K Reggio, A
Citation
F. Nicoletti et al., Increased serum levels of interleukin-18 in patients with multiple sclerosis, NEUROLOGY, 57(2), 2001, pp. 342-344
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
57
Issue
2
Year of publication
2001
Pages
342 - 344
Database
ISI
SICI code
0028-3878(20010724)57:2<342:ISLOII>2.0.ZU;2-F
Abstract
Serum but not CSF concentrations of the interferon-gamma -inducing cytokine interleukin (IL)-18 were significantly augmented in patients with MS as co mpared to both healthy controls and patients with other neurologic diseases . Patients with MS with secondary chronic progressive disease had significa ntly higher serum levels than those with relapsing remitting MS. In the lat ter group, IL-18 levels were higher in patients with acute exacerbation as compared to those with stable disease.