Scavenging of fluorinated N,N '-dialkylureas by hydrogen binding: A novel separation method for fluorous synthesis

Authors
Palomo, C Aizpurua, JM Loinaz, I Fernandez-Berridi, MJ Irusta, L
Citation
C. Palomo et al., Scavenging of fluorinated N,N '-dialkylureas by hydrogen binding: A novel separation method for fluorous synthesis, ORG LETT, 3(15), 2001, pp. 2361-2364
Citations number
27
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
15
Year of publication
2001
Pages
2361 - 2364
Database
ISI
SICI code
1523-7060(20010726)3:15<2361:SOFN'B>2.0.ZU;2-4
Abstract
[GRAPHICS] A dramatic solubility increase in fluorous solvents is observed for N,N ' - di(polyfluoroalkyl)ureas when hydrogen binding complexes are formed with co mmercially available perfluoroalkanoic acid scavengers. As a case example, analytically pure peptides and esters are obtained using this novel separat ion method.