Hj. Feickert et al., Incidence, impact on survival, and risk factors for multi-organ system failure in children following liver transplantation, PEDIAT TRAN, 5(4), 2001, pp. 266-273
Liver transplantation (LTx) in children currently offers longterm survival
rates of more than 80%. Many causes for Tx failure have been identified. Ho
wever, the incidence and impact of multi-organ system failure (MOSF) are. t
o date, unknown. Therefore, in this study the role of MOSF after LTx in chi
ldren was investigated with regard to outcome. The data of 114 children (53
girls, 61 boys: median age 4.3 yr) after first LTx were evaluated retrospe
ctively. The definition of MOSF, as used by Wilkinson et al. [Crit Care Med
1986: 14: 271-274], was modified with regard to age-adjusted values. The i
nfluence of MOSF on patient survival was investigated by Kaplan-Meier analy
sis and multivariate regression analysis. Thirty-one of 114 children with o
rthotopic LTx developed MOSF (involving two or more organs), In total, 18 c
hildren died (15.8%) during the hospitalization; 16 of these had MOSF. Mort
ality related to two-organ failure was 29.4% (n=5), to three-organ failure
78% (n=7), and to four-organ failure 80%, (n=4). The highest mortality rate
s were observed in children with central nervous system (CNS) and cardiovas
cular failure, leading to a decreased probability of survival of 0.40 (p <0
.0001). Multi-variate analysis showed that CNS and cardiovascular failure w
ere the most important risk factors for survival (p <0.0001 and 0.056, resp
ectively). Respiratory and renal failure, in univariate analysis, were sign
ificant contributors to poor survival, but had no statistically significant
influence on outcome in multivariate analysis. Bone marrow insufficiency w
as found to have no influence on survival in either analysis. In multivaria
te analysis. the risk of development of MOSF was significantly increased by
high numbers of transfused units of fresh-frozen plasma (FFP), the absence
of rejection episodes, or a high bilirubin level prior to Tx. Hence, MOSF
is a major factor contributing to the death of children early after LTx. CN
S and cardiovascular failure carried the highest risk for a poor outcome. O
ther risk factors associated with the development of MOSF were: numbers of
transfused units of FFP, absence of rejection episodes, and a high pre-Tx b
ilirubin level.