Citation
A. Vitali et al., Synthesis and biosynthesis of isocordoin, PLANTA MED, 67(5), 2001, pp. 475-477
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943
→ ACNP
Volume
67
Issue
5
Year of publication
2001
Pages
475 - 477
Database
ISI
SICI code
0032-0943(200107)67:5<475:SABOI>2.0.ZU;2-B
Abstract
In the search of a convenient synthesis for isocordoin (1), a potential ant
icancer natural product, 2 ' ,4 ' -dihydroxychalcone was inoculated in cell
suspension cultures of Morus nigro, which were expected to contain an acti
ve prenyltransferase. After 24 hours the target compound was easily isolate
d from the metabolite extract. Optimization of the biotransformation result
ed in a 85% yield of the prenyl derivative.