Are proinflammatory cytokine concentrations reduced by plasma exchange in patients with severe acute hepatic failure?

Authors
Nakae, H Yonekawa, T Narita, K Endo, S
Citation
H. Nakae et al., Are proinflammatory cytokine concentrations reduced by plasma exchange in patients with severe acute hepatic failure?, RES COM M P, 109(1-2), 2001, pp. 65-72
Citations number
19
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY
ISSN journal
10780297 → ACNP
Volume
109
Issue
1-2
Year of publication
2001
Pages
65 - 72
Database
ISI
SICI code
1078-0297(2001)109:1-2<65:APCCRB>2.0.ZU;2-U
Abstract
We studied citric acid levels and proinflammatory cytokines (TNF-alpha, IL- 6, and IL-8) before and after plasma exchange in 8 patients with acute live r failure. Plasma exchange was performed over a 6 to 7-hour period. At each session, 3.6 to 4.0 1 of plasma was exchanged for the same volume of fresh frozen plasma (FFP). The concentrations of citric acid were significantly increased after plasma exchange above concentrations before exchange (p<0.0 001). There were no significant differences in TNF-<alpha>, IL-6, or IL-8 c oncentrations (p=0.7222, p=0.9357, p=0.6394, respectively). Thus, plasma ex change with FFP alone may not effectively remove cytokines.