Nerve growth factor and striatal glutathione metabolism in a rat model of Huntington's disease

Authors
Cruz-Aguado, R Turner, LF Diaz, CM Pinero, J
Citation
R. Cruz-aguado et al., Nerve growth factor and striatal glutathione metabolism in a rat model of Huntington's disease, REST NEUROL, 17(4), 2000, pp. 217-221
Citations number
28
Categorie Soggetti
Neurosciences & Behavoir
Journal title
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
ISSN journal
09226028 → ACNP
Volume
17
Issue
4
Year of publication
2000
Pages
217 - 221
Database
ISI
SICI code
0922-6028(2000)17:4<217:NGFASG>2.0.ZU;2-0
Abstract
Purpose: To test the influence of nerve growth factor (NGF) on striatal glu tathione (GSH) content and the activities of GSH-related enzymes from quino linic acid-lesioned rats. Methods: Rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed one week later. Results: NGF prevented the QA-induced decline in glutathione reductase acti vity and GSH content. Conclusions: NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism.