KOH-promoted reaction of C,O,O-tris(trimethylsilyl) ketene acetal with aldehydes: Practical and easy access to (E)-alpha,beta-ethylenic carboxylic acids

Authors
Lensen, N Mouelhi, S Bellassoued, M
Citation
N. Lensen et al., KOH-promoted reaction of C,O,O-tris(trimethylsilyl) ketene acetal with aldehydes: Practical and easy access to (E)-alpha,beta-ethylenic carboxylic acids, SYN COMMUN, 31(7), 2001, pp. 1007-1011
Citations number
18
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
7
Year of publication
2001
Pages
1007 - 1011
Database
ISI
SICI code
0039-7911(2001)31:7<1007:KROCKA>2.0.ZU;2-B
Abstract
The use of a catalytic amount of KOH has been found to be very efficient in promoting reaction of silylketene acetal 1 with aldehydes 2 to afford the corresponding (E)-alpha,beta -ethylenic carboxylic acids 3 under very mild conditions.