Practical synthesis of ethyl cis-4-amino-3-methoxy-1-piperidine carboxylate, a key intermediate of cisapride

Authors
Kim, BJ Pyun, DK Jung, HJ Kwak, HJ Kim, JH Kim, EJ Jeong, WJ Lee, CH
Citation
Bj. Kim et al., Practical synthesis of ethyl cis-4-amino-3-methoxy-1-piperidine carboxylate, a key intermediate of cisapride, SYN COMMUN, 31(7), 2001, pp. 1081-1089
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
7
Year of publication
2001
Pages
1081 - 1089
Database
ISI
SICI code
0039-7911(2001)31:7<1081:PSOECC>2.0.ZU;2-I
Abstract
A practical synthesis of ethyl cis-4-amino-3-methoxy-1-piperidinecarboxylat e 1, a key intermediate of cisapride as a potent gastrointestinal stimulant , has been accomplished from 1-methyl-1,2,3,6-tetrahydropyridine 2 via an e fficient formation of eis-fused oxazolidinopiperidine 7.