Synthesis of (S)-(+)-2-amino-6-(aminooxy)-hexanoic acid

Authors
Adamczyk, M Reddy, RE
Citation
M. Adamczyk et Re. Reddy, Synthesis of (S)-(+)-2-amino-6-(aminooxy)-hexanoic acid, SYN COMMUN, 31(4), 2001, pp. 579-586
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
4
Year of publication
2001
Pages
579 - 586
Database
ISI
SICI code
0039-7911(2001)31:4<579:SO(A>2.0.ZU;2-3
Abstract
(S)-2-Amino-6-(aminooxy)hexanoic acid (AAHA, 3), a non-proteinogenic amino acid, and its derivative, (S)-(-)-6-{[(tert-butoxycarbonyl)amino]oxy}-2-{[( 9H-fluoren-9-ylmethoxy)-carbonyl]amino}hexanoic acid (4), were synthesized from (S)-(-)-6-amino-2-{[(benzyloxy)carbonyl] amino}hnoic acid (5) in good overall yield.