A. Kakefuda et al., An efficient synthesis of (+/-)-6,7-dimethoxy-1-oxo-2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline, SYN COMMUN, 31(3), 2001, pp. 401-408
The synthesis of (+/-)-6,7-dimethoxy-1-oxo-2-(3-piperidyl)-1,2,3,4-tetrahyd
roisoquinoline (1) via the cyclization of dimethyl-acetal (3) under acidic
condition is described.