The use of malononitrile in the synthesis of novel alpha-amino nitriles

Authors
Metwally, MA Mogieb, MA
Citation
Ma. Metwally et Ma. Mogieb, The use of malononitrile in the synthesis of novel alpha-amino nitriles, SYN COMMUN, 31(12), 2001, pp. 1901-1905
Citations number
10
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
12
Year of publication
2001
Pages
1901 - 1905
Database
ISI
SICI code
0039-7911(2001)31:12<1901:TUOMIT>2.0.ZU;2-K
Abstract
Continuing earlier studies designed to obtain compounds of pharmaceutical i nterest, we used acetyl acetone (1, R=CH3) and ethyl acetoacetate (1, R=OEt ) for the preparation of some novel alpha -amino nitriles (3, 6 and 7). The structures of the new ring systems have been confirmed by IR, NMR and mass spectral data.