An enantioselective approach to bis-alpha-amino acids

Authors
Lygo, B Crosby, J Peterson, JA
Citation
B. Lygo et al., An enantioselective approach to bis-alpha-amino acids, TETRAHEDRON, 57(30), 2001, pp. 6447-6453
Citations number
64
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
30
Year of publication
2001
Pages
6447 - 6453
Database
ISI
SICI code
0040-4020(20010723)57:30<6447:AEATBA>2.0.ZU;2-7
Abstract
In this paper, we describe details of a study into the asymmetric synthesis of bis-alpha -amino acids via alkylation of a benzophenone-derived glycine imine under phase-transfer conditions. By employing chiral quaternary ammo nium salts derived from cinchona alkaloids it was found that the target bis -amino acids can be produced in good overall yield, and with high levels of stereoselectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.