Zamamistatin, a significant antibacterial bromotyrosine derivative, from the Okinawan sponge Pseudoceratina purpurea

Authors
Takada, N Watanabe, R Suenaga, K Yamada, K Ueda, K Kita, M Uemura, D
Citation
N. Takada et al., Zamamistatin, a significant antibacterial bromotyrosine derivative, from the Okinawan sponge Pseudoceratina purpurea, TETRAHEDR L, 42(31), 2001, pp. 5265-5267
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
31
Year of publication
2001
Pages
5265 - 5267
Database
ISI
SICI code
0040-4039(20010730)42:31<5265:ZASABD>2.0.ZU;2-Q
Abstract
Zamamistatin was isolated from the Okinawan sponge Pseudoceratina purpurea. It was determined to be a novel bromotyrosine derivative by careful analys is of 2D NMR spectra and comparison of its H-1 NMR spectrum with those of s tructurally related compounds. The absolute stereostructure of zamamistatin was determined by the modified Mosher's method. Zamamistatin exhibited sig nificant antibacterial activity against Rhodospirillum salexigens, which ha s adhering properties. (C) 2001 Elsevier Science Ltd. All rights reserved.