Synthesis of the biaryl moiety of the proteasome inhibitors TMC-95 via a ligandless Pd(OAc)(2)-catalyzed Suzuki-coupling reaction

Authors
Ma, DW Wu, QQ
Citation
Dw. Ma et Qq. Wu, Synthesis of the biaryl moiety of the proteasome inhibitors TMC-95 via a ligandless Pd(OAc)(2)-catalyzed Suzuki-coupling reaction, TETRAHEDR L, 42(31), 2001, pp. 5279-5281
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
31
Year of publication
2001
Pages
5279 - 5281
Database
ISI
SICI code
0040-4039(20010730)42:31<5279:SOTBMO>2.0.ZU;2-A
Abstract
The biaryl moiety of proteasome inhibitors TMC-95 was synthesized via a Pd( OAc)(2)-catalyzed Suzuki-coupling reaction of 7-iodoisatin and a tyrosine-d erived arylboronic acid in the absence of phosphine ligands using potassium fluoride as a base. (C) 2001 Elsevier Science Ltd. All rights reserved.