Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac

The use of protease Inhibitors (PI) has been associated with many adverse e ffects including increased tendency to bleed, which is particularly problem atic in individuals with congenital coagulation disorders. We report the oc currence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprena vir (APV). The bleeding resolved on discontinuation of APV. This case repor t highlights a need for awareness of increased bleeding as a potentially se rious complication associated with the use of all currently licensed PIs in individuals with hemophilia.