L. Calza et al., Osteonecrosis and highly active antiretroviral therapy during HIV infection: Report of a series and literature review, AIDS PAT CA, 15(7), 2001, pp. 385-389
Osteonecrosis has shown an increased incidence in HIV-infected patients dur
ing the last few years, and has been looked as a side effect of highly acti
ve antiretroviral therapy, possibly related to hyperlipidemia. Five cases o
f osteonecrosis were observed among over 1300 patients with HIV disease. Ac
cording to our experience, novel antiretroviral regimens do not represent a
constant risk factor for avascular necrosis of bone during HIV infection.