Patients with psychiatric illness smoke more heavily than others in the com
munity. They have more difficulty quitting and have more withdrawal symptom
s than others. Objective: The purpose of the present study was to examine t
he utilization of nicotine replacement methods in a population of psychiatr
ic patients. Method: In a naturalistic retrospective review, we examined th
e records of 55 patients who were hospitalized on a smoke-free psychiatric
unit. We abstracted the frequency of utilization of nicotine replacement. T
he rate of utilization was considered a ratio of the number of days utilize
d to the number of days prescribed. Results: There were 38 patients (69%) w
ho used the transdermal patch, 26 patients (47%) used the inhaler, 4 patien
ts (7%) used nicotine gum, and 2 patients (4%) used the nasal spray. The ra
te of utilization of the nicotine inhaler (63%) exceeded that of the transd
ermal nicotine patch (30%) (t = 4.6, p < .0001). Conclusion: The hospitaliz
ation of smokers with mental illness in smoke-free psychiatric units often
leads to further behavioral deterioration. The patients in the present stud
y demonstrated a definite preference for the nicotine inhaler over the tran
sdermal patch. Possible clinical and pathophysiological implications of thi
s finding are discussed.