Immunotactoid glomerulopathy with massive bone marrow deposits in a patient with IgM kappa monoclonal gammopathy and hypocomplementemia

A case of immunotactoid glomerulopathy with an amyloid-like material in the glomeruli and bone marrow is described. Clinically the patient was diagnos ed as having severe nephrotic syndrome, hypocomplementemia, and IgM kappa m onoclonal gammopathy. Immunotactoid glomerulopathy is an unusual cause of g lomerulonephritis, characterized by Congo red-negative, amyloid-like deposi ts in the glomeruli. This unusual case presentation shows that immunotactoi d glomerulopathy may be a manifestation of systemic disease. This patient a lso presented with hypocomplementemia, an extremely rare associated finding that has been reported previously in only four cases of immunotactoid glom erulopathy. (C) 2001 by the National Kidney Foundation, Inc.