No association between a promoter dopamine D-4 receptor gene variant and schizophrenia

Authors
Jonsson, EG Ivo, R Forslund, K Mattila-Evenden, M Rylander, G Cichon, S Propping, P Nothen, MM Asberg, M Sedvall, GC
Citation
Eg. Jonsson et al., No association between a promoter dopamine D-4 receptor gene variant and schizophrenia, AM J MED G, 105(6), 2001, pp. 525-528
Citations number
41
Categorie Soggetti
Molecular Biology & Genetics
Journal title
AMERICAN JOURNAL OF MEDICAL GENETICS
ISSN journal
01487299 → ACNP
Volume
105
Issue
6
Year of publication
2001
Pages
525 - 528
Database
ISI
SICI code
0148-7299(20010808)105:6<525:NABAPD>2.0.ZU;2-A
Abstract
The dopamine D-4 receptor has been implicated in the pathogenesis of schizo phrenia. An association between a putative functional promoter polymorphism (-521C/T) in the dopamine D-4 receptor gene (DRD4) and schizophrenia was r ecently reported. In the present study, patients with schizophrenia (n = 13 2) and control subjects (n = 388) were analyzed with respect to the DRD4 - 521C/T polymorphism. No significant case control differences emerged. The p resent results do not support a major role for DRD4 in the etiology of schi zophrenia among Caucasians from Sweden. (C) 2001 Wiley-Liss, Inc.