Panniculitis induced by MINE chemotherapy

Background. Drug-induced panniculitis are uncommon. We report the second ca se of panniculitis induced by MINE chemotherapy. Case report. A 31-year-old woman with relapsed Hodgkin disease was treated with MINE cytostatic regimen. Multiple erythematous and painful nodules of panniculitis developed on her chest, abdomen and thighs fifteen days after the beginning of drug administration with a second flare up after second ad ministration of the same drugs. The eruption cleared slowly after treatment withdrawal. Discussion. To our knowledge, our case is the second reported case of panni culitis induced by MINE chemotherapy. Drug-induced panniculitis is uncommon and usually induced by steroid treatment. Some cases of panniculitis induc ed by atenolol, potassium bromide, apomorphine, interferon alpha and interl eukin 2 have been described. Few cutaneous adverse effects are reported wit h MINE chemotherapy rash, erythema and swelling of extremities. A case of i nflammatory swelling of thighs with hemorrhagic panniculitis due to this tr eatment has been described recently.