Impact of delayed gastric emptying on the outcome of antireflux surgery

Objective To study the effect of Nissen fundoplication on the pattern of gastric empt ying and intragastric distribution of symptoms in patients with normal and delayed gastric emptying before surgery, especially in those with delayed e mptying before surgery. Summary Background Data Gastroesophageal reflux disease is associated with delayed gastric emptying and dyspeptic symptoms in approximately 40% of the patients. After Nissen fundoplication, dyspeptic symptoms are also not uncommon. Methods Thirty-six patients (26 men, 10 women, mean age 43.1) were studied before a nd 3 months after Nissen fundoplication. Gastric emptying (dual-isotope, ex pressed in lag phase, emptying rate, T-50, and intragastric distribution) w as not included in the decision for surgery. Reflux-related and dyspeptic s ymptoms were scored before and at 3, 6, and 12 months after surgery. Results Twenty-six patients had normal and 10 had delayed gastric emptying before s urgery. Nissen fundoplication on average enhanced gastric emptying for soli ds in both subgroups by a combination of a decrease in mean lag phase, empt ying rate, and T-50. The preoperative difference in intragastric distributi on between patients with and without delayed gastric emptying was abolished by fundoplication. Patients with normal gastric emptying before surgery sh owed an increase in early postprandial satiety; in those with delayed empty ing, this was not observed. A correlation was found between preoperative To for liquid gastric emptying and postoperative nausea at 3 months in patien ts with normal gastric emptying. In patients with delayed emptying, preoper ative correlations between lag phase for liquids and nausea respectively ea rly satiety were significant, as well as for T-50 for liquids and vomiting. Conclusions Nissen fundoplication equalizes the preoperative difference in intragastric distribution and accelerates gastric emptying without an effect on symptom s in patients with preexisting delayed gastric emptying, but with an increa se in early satiety in patients with normal gastric emptying. Delayed gastr ic emptying is not a contraindication for antireflux surgery.