Sequential changes in the metabolic response to orthotopic liver transplantation during the first year after surgery

Objective To quantify the sequential changes in the metabolic response occurring in p atients with end-stage liver disease after orthotopic liver transplantation (OLT). Summary Background Data Detailed quantification of the changes in energy expenditure, body composit ion, and physiologic function that occur in patients after OLT has not been performed, Understanding these changes is essential for the optimal manage ment of these patients. Methods Fourteen patients who underwent OLT for end-stage liver disease had measure ments of resting energy expenditure, body composition, and physiologic func tion immediately before surgery and 5, 10, 15, 30, 90, 180, and 360 days la ter. Results Resting energy expenditure was significantly elevated after surgery (24% ab ove predicted), peaking around day 10 after OLT, when it averaged 42% above predicted, A significant degree of hypermetabolism was still present at 6 months, but at 12 months measured resting energy expenditure was close to p redicted values. Before surgery, measured total body protein was 82% of est imated preillness total body protein. During the first 10 days after OLT, a further 1.0 kg (10%) of total body protein was lost, mostly from skeletal muscle. Only 54% of this loss was restored by 12 months. Significant overhy dration of the fat-free body was seen before OLT, and it was still present 12 months later. Although significant losses of body fat and bone mineral o ccurred during the early postoperative period, only body fat stores were re stored at 12 months. Both subjective fatigue score and voluntary hand grip strength improved rapidly after OLT to exceed preoperative levels at 3 mont hs. At 12 months grip strength was close to values predicted for these pati ents when well. Respiratory muscle strength improved less markedly and was significantly lower than predicted normal levels at 12 months. Conclusions Before surgery, these patients were significantly protein-depleted, overhyd rated, and hypermetabolic. After surgery, the period of hypermetabolism was prolonged, restoration of body protein stores was gradual and incomplete, and respiratory muscle strength failed to reach expected normal values. Our measurements indicate that OLT does not normalize body composition and fun ction and imply that a continuing metabolic stress persists for at least 12 months after surgery.