Methodologies for the stereoselective synthesis of adrenergic beta-blockers: An overview

Authors
Campo, C Llama, EF Bermudez, JL Sinisterra, JV
Citation
C. Campo et al., Methodologies for the stereoselective synthesis of adrenergic beta-blockers: An overview, BIOCATAL B, 19(3), 2001, pp. 163-180
Citations number
33
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCATALYSIS AND BIOTRANSFORMATION
ISSN journal
10242422 → ACNP
Volume
19
Issue
3
Year of publication
2001
Pages
163 - 180
Database
ISI
SICI code
1024-2422(2001)19:3<163:MFTSSO>2.0.ZU;2-6
Abstract
The importance of the adrenergic beta -blockers with structure of (S) 1-ary loxy-3-amino-2-propanol in the treatment of different diseases has led the development of a variety of stereoselective synthetic methodologies for thi s stereoisomer. In this review we present several methodologies to obtain t his compound using (i) chiral substrates, (ii) chiral catalysts (organometa llic or enzymes) and (iii) preparative chiral chromatography, showing the a dvantages and disadvantages of each methodology.