Synthesis and biological evaluation of methoxyphenyl porphyrin derivativesas potential photodynamic agents

Authors
Milanesio, ME Moran, FS Yslas, EI Alvarez, MG Rivarola, V Durantini, EN
Citation
Me. Milanesio et al., Synthesis and biological evaluation of methoxyphenyl porphyrin derivativesas potential photodynamic agents, BIO MED CH, 9(8), 2001, pp. 1943-1949
Citations number
34
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
8
Year of publication
2001
Pages
1943 - 1949
Database
ISI
SICI code
0968-0896(200108)9:8<1943:SABEOM>2.0.ZU;2-P
Abstract
A new meso-2,4,6-trimethoxyphenyl porphyrin covalently linked to a 2 ' ,6 ' -dinitro-4 ' -trifluoromethylphenyl group by an amine bond 5 and its metal complex with Cd(II) 6 was prepared. The photodynamic activities of 5 and 6 were evaluated in vitro on Hep-2 cells. A considerable increase in the pho tocytotoxic effect was found for 6, which has higher singlet molecular oxyg en, O-2((1)A(g)), production. (C) 2001 Elsevier Science Ltd. All rights res erved.