Synthesis and QSAR studies of 4-substituted phenyl-2,6-dimethyl-3, 5-bis-N-(substituted phenyl)carbamoyl-1,4-dihydropyridines as potential antitubercular agents

Authors
Desai, B Sureja, D Naliapara, Y Shah, A Saxena, AK
Citation
B. Desai et al., Synthesis and QSAR studies of 4-substituted phenyl-2,6-dimethyl-3, 5-bis-N-(substituted phenyl)carbamoyl-1,4-dihydropyridines as potential antitubercular agents, BIO MED CH, 9(8), 2001, pp. 1993-1998
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
8
Year of publication
2001
Pages
1993 - 1998
Database
ISI
SICI code
0968-0896(200108)9:8<1993:SAQSO4>2.0.ZU;2-7
Abstract
Synthesis and QSAR studies of the title compounds have resulted in the iden tification of structural and physicochemical parameters (MR, sigma (o), sig ma (m), sigma (p)) contributing to antitubercular activity. Among these, ca rbamoyl phenyl ring substituted at 3 and 4 position with NO2 group or 2 pos ition with Cl or OCH3 group shows > 90% inhibition against H37R nu comparab le to other substituted phenyls. (C) 2001 Elsevier Science Ltd. All rights reserved.