Synthesis and pharmacological activity of metabolites of the 5-HT4 receptor antagonist SB-207266

Authors
Fedouloff, M Hossner, F Voyle, M Ranson, J Powles, J Riley, G Sanger, G
Citation
M. Fedouloff et al., Synthesis and pharmacological activity of metabolites of the 5-HT4 receptor antagonist SB-207266, BIO MED CH, 9(8), 2001, pp. 2119-2128
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
8
Year of publication
2001
Pages
2119 - 2128
Database
ISI
SICI code
0968-0896(200108)9:8<2119:SAPAOM>2.0.ZU;2-V
Abstract
Three metabolites of N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3] -oxazino[3,2_a]indole-10-carboxamide (SB-207266) (1) were synthesised and t heir pharmacological activity determined. (C) 2001 Elsevier Science Ltd. Al l rights reserved.