3-arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as anti-inflammatory and analgesic agents

Authors
Schenone, S Bruno, O Ranise, A Bondavalli, F Filippelli, W Falcone, G Giordano, L Vitelli, MR
Citation
S. Schenone et al., 3-arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as anti-inflammatory and analgesic agents, BIO MED CH, 9(8), 2001, pp. 2149-2153
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
8
Year of publication
2001
Pages
2149 - 2153
Database
ISI
SICI code
0968-0896(200108)9:8<2149:3AA>2.0.ZU;2-A
Abstract
Two series of 3-arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones 2 with potential anti-inflammatory and analgesic activity were prepared and teste d. Pharmacological results revealed that all the title compounds, endowed w ith an arylsulphonyl side chain, possess good antalgic activity and fair an ti-inflammatory properties. The analgesic profile of the two series, evalua ted by the acetic acid writhing test, showed that compouds 2c, 2f and 2h, i n particular, were the most active. Structure-activity relationships are br iefly discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.