Fibroadenoma with atypical giant cells occuring in Li Fraumeni Syndrome

This report describes a patient with Li Fraumeni Syndrome who first present ed with an unusual fibroadenoma containing atypical multinucleated giant ce lls. These cells are thought to be fibrohistiocytic in nature and are rarel y seen in fibroepithelial lesions of the breast. Previously these cells wer e considered incidental in nature. The possibility of Li Fraumeni Syndrome needs to be considered when such features are encountered in future. (C) 20 01 Harcourt Publishers Ltd.