Amoxapine shows an antipsychotic effect but worsens motor function in patients with Parkinson's disease and psychosis

Amoxapine, a dibenzoxazepine antidepressant, has been suggested to have aty pical antipsychotic properties. We tested it to control psychosis ill three patients with Parkinson's disease (PD). Two patients had significant impro vement in hallucinations, whereas the third could not tolerate the drug for a sufficient period. All three patients experienced a decline in motor fun ction; two also had concomitant reduction ill dyskinesias. Therefore, altho ugh we found some support for amoxapine having antipsychotic properties, th is drug seems to carry a risk of worsening motor function ill patients with PD.