Genomic organization and mapping of the gene (SW25A19) encoding the human mitochondrial deoxynucleotide carrier (DNC)

Authors
Iacobazzi, V Ventura, M Fiermonte, G Prezioso, G Rocchi, M Palmieri, F
Citation
V. Iacobazzi et al., Genomic organization and mapping of the gene (SW25A19) encoding the human mitochondrial deoxynucleotide carrier (DNC), CYTOG C GEN, 93(1-2), 2001, pp. 40-42
Citations number
12
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
93
Issue
1-2
Year of publication
2001
Pages
40 - 42
Database
ISI
SICI code
0301-0171(2001)93:1-2<40:GOAMOT>2.0.ZU;2-M
Abstract
The deoxynucleotide carrier (DNC) transports deoxynucleotides into mitochon dria and is therefore essential for mtDNA synthesis. The human DNC gene (SL C25A19) spans about 16.5 kb and consists of nine exons with the translation start site in exon 4. It is located on chromosome 17q25.3. Three transcrip ts, which differ in their 5' ends and are generated by alternative splicing , have been identified. Copyright (C) 2001 S. Karger AG, Basel.