The glypicans compose a family of glycosylphosphatidylinositol (GPI)-anchor
ed heparan sulfate proteoglycans that play a role in the control of cell di
vision and growth regulation. So far, six members (GPC 1-6) of this family
are known in vertebrates. The rat glypican gene 3 (Gpc3) was previously ass
igned to chromosome Xq36 (Shen et al., 1997). Using standard and radiation
cell hybrids, we localized the five other rat glypican genes. Copyright (C)
2001 S. Karger AG, Basel.