Organization and chromosomal localization of the human and mouse genes coding for LanC-like protein 1 (LANCL1)

We have determined the organization and chromosome location of the human LA NCL1 and mouse Lancl1 genes encoding LANCL1, the lanthionine synthetase com ponent C (LanC)-like protein 1. LANCL1 is related to the bacterial LanC fam ily which is involved in the biosynthesis of antimicrobial peptides. The hu man and mouse genes span 45 kb and 38 kb, respectively, each comprising ten exons. Within the potential promoter regions. several consensus sequences for ubiquitous and tissue-specific transcription factors are present, refle cting the expression data. The nucleotide sequence of the previously unknow n mouse full-length transcript is also reported here. Fluorescence in situ hybridization analyses assigned the LANCL1 gene to human chromosome 2q34 an d the Lancl1 gene to mouse chromosome 1, region C2-C5, in accordance with t he known homology. Copyright (C) 2001 S. Karger AG, Basel.