Corticosteroid-induced osteoporosis - Detection and management

Citation
Jd. Adachi et A. Papaioannou, Corticosteroid-induced osteoporosis - Detection and management, DRUG SAFETY, 24(8), 2001, pp. 607-624
Citations number
168
Categorie Soggetti
Pharmacology
Journal title
DRUG SAFETY
ISSN journal
01145916 → ACNP
Volume
24
Issue
8
Year of publication
2001
Pages
607 - 624
Database
ISI
SICI code
0114-5916(2001)24:8<607:CO-DAM>2.0.ZU;2-4
Abstract
Corticosteroid-induced osteoporosis is a major cause of morbidity and is th e leading secondary cause of osteoporosis today. Unfortunately, despite thi s knowledge, patients receiving corticosteroid therapy are often not offere d any preventative treatment. Recent research has focused attention on the critical role the osteoblast has played in the pathophysiology of corticost eroid-induced osteoporosis. In addition to an initial increase in bone reso rption, there is evidence that corticosteroids induce osteoblast and osteoc yte apoptosis and as a result are important contributors to bone loss. Inte resting work has suggested that the bisphosphonates and calcitonin may help to prevent osteoblast apoptosis from occurring. Large scale randomised con trolled trials have also been completed with a variety of therapeutic agent s. Of the many different therapies, it is now clear that the bisphosphonate s have the greatest evidence to support their use. Increases in bone minera l density when compared with a control group, not only at the spine but als o at the hip, have been demonstrated. These studies have shown clinically s ignificant reductions in vertebral fracture rates seen for the most part in postmenopausal women. Other therapies may well be effective, as evidenced by maintenance of bone mass in the spine; however, maintenance of bone mass in the hip and reductions in fracture rate have yet to be demonstrated for many of these therapies, Given our current knowledge and the evidence that is outlined in this review, it is hoped that patients who require therapy with corticosteroids for more than 3 months will be offered appropriate pre ventative treatment.