D. Poldermans et al., Bisoprolol reduces cardiac death and myocardial infarction in high-risk patients as long as 2 years after successful major vascular surgery, EUR HEART J, 22(15), 2001, pp. 1353-1358
Aim To assess the long-term cardioprotective effect of bisoprolol in a rand
omized high-risk population after successful major vascular surgery. High-r
isk patients were defined by the presence of one or more cardiac risk facto
r(s) and a dobutamine echocardiography test positive for ischaemia.
Methods 1351 patients were screened prior to surgery, 846 patients had one
or more risk factor(s), and 173 of these patients also had ischaemia during
dobutamine echocardiography. One hundred and twelve patients could be rand
omized for additional bisoprolol therapy or standard care. Eleven patients
died in the peri-operative period (up to 1 month after surgery). Randomized
patients continued bisoprolol or standard care after surgery. During follo
w-up of 101 survivors (median 22 months, range 11-30) cardiac death or myoc
ardial infarction was noted. No patient was lost during follow-up.
Results The incidence of cardiac events during follow-up in the bisoprolol
group was 12% vs 32% in the standard care group (P=0.025). Cardiac death oc
curred in 15 patients, nine patients in the standard care and in six in the
bisoprolol group; myocardial infarction occurred in six patients, five in
the standard care and one in the bisoprolol group. The odds ratio for cardi
ac death or myocardial infarction after surgery in high-risk patients with
additional bisoprolol therapy was 0.30 (0.11-0.83).
Conclusions Bisoprolol significantly reduced long-term cardiac death and my
ocardial infarction in high-risk patients after successful major cardiac va
scular surgery.