Endometrial biopsy during outpatient hysteroscopy: evaluation and comparison of two devices

Citation
A. Agostini et al., Endometrial biopsy during outpatient hysteroscopy: evaluation and comparison of two devices, EUR J OB GY, 97(2), 2001, pp. 220-222
Citations number
17
Categorie Soggetti
Reproductive Medicine
Journal title
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
ISSN journal
03012115 → ACNP
Volume
97
Issue
2
Year of publication
2001
Pages
220 - 222
Database
ISI
SICI code
0301-2115(200108)97:2<220:EBDOHE>2.0.ZU;2-X
Abstract
Objective: Association of office hysteroscopy with outpatient endometrial b iopsy is interesting to evaluate correctly endometrium. Purpose of this stu dy was to evaluate and compare two endometrial biopsy devices during outpat ient hysteroscopy, based on effectiveness and tolerance of the procedure. S tudy Design: A single blind, randomised prospective study. Results: 200 pat ients were randomised into two groups following outpatient hysteroscopy: 10 0 were biopsied with Vacurette and 100 biopsed with Pipelle. Pipelle was le ss painful compared to Vacurette (1.1 + 0.2 versus 1.6 + 0.3; P < 0.001), n o matter hormonal status (1 + 0.3 versus 2 + 0.6; P < 0.001 in premenopausa l subgroup and 1 + 0.3 versus 1.4 + 0.3; P < 0.001 in postmenopausal subgro up). Vacurette was more effective than Pipelle (64/100 versus 48/100; P = 0 .02), in case of normal or hypertrophic endometrium (56/72 (77%) versus 40/ 65 (61%); P = 0.04) but not in case of atrophic endometrium (8/28 (29%) ver sus 8/35 (23%); P = 0.6). Among the 112 patients with adequate sample, hist ologic results were normal, except for three cases of endometrial hyperplas ia. Among the 88 patients with inadequate sample, 47 (53%) presented an atr ophic endometrial aspect at hysteroscopy, whereas 41 (47%) were considered as normal. Conclusions: Vacurette was snore effective though more painful t han Pipelle. Both instruments were, however, well tolerated. Both instrumen ts were not very effective in case of atrophic endometrium. Outpatient hyst eroscopy combined with endometrial biopsy may help avoid further investigat ions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.