Topically applied liposome encapsulated superoxide dismutase reduces postburn wound size and edema formation

Citation
K. Vorauer-uhl et al., Topically applied liposome encapsulated superoxide dismutase reduces postburn wound size and edema formation, EUR J PH SC, 14(1), 2001, pp. 63-67
Citations number
21
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN journal
09280987 → ACNP
Volume
14
Issue
1
Year of publication
2001
Pages
63 - 67
Database
ISI
SICI code
0928-0987(200108)14:1<63:TALESD>2.0.ZU;2-2
Abstract
The overproduction of biochemical mediators, and activation of leukocytes a nd endothelial cells, generated in thermally injured tissue. gives rise to both local and distant effects. The formation of short-lived, highly reacti ve metabolites. such as oxygen free radicals, increases with increasing tis sue ischemia, and causes further cell damage. Human recombinant Cu/Zn-super oxide dismutase (rh-Cu/Zn-SOD), an enzyme which captures these radicals. ma y have a beneficial effect on the postburn inflammation processes. In this study, the influence of rh-Cu/Zn-SOD application to thermally injured tissu e of rabbit backskin was examined. Three different delivery strategies were compared. pure or liposomally encapsulated enzyme. or intralesionally inje cted rh-Cu/Zn-SOD. For control, one animal group was treated with plain gel and another group was kept untreated. At 24 In following trauma a statisti cally significant difference in lesion sizes between the enzyme treated and control groups was observed. After 72 It tissue swelling had diminished si gnificantly more in the rh-Cu/Zn-SOD treated groups as compared to the cont rol animals. The best results were achieved by spreading liposomes encapsul ating the enzyme onto the wounds. Our results suggest that local treatment of burn wounds with enzymatic radical scavengers such as rh-Cu/Zn-SOD has a beneficial effect on the extent of the postburn damage. (C) 2001 Elsevier Science BY All rights reserved.