Hydrolysis of tRNA(Phe) on suspensions of amino acids

Authors
Gao, K Orgel, LE
Citation
K. Gao et Le. Orgel, Hydrolysis of tRNA(Phe) on suspensions of amino acids, HELV CHIM A, 84(6), 2001, pp. 1347-1354
Citations number
50
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
HELVETICA CHIMICA ACTA
ISSN journal
0018019X → ACNP
Volume
84
Issue
6
Year of publication
2001
Pages
1347 - 1354
Database
ISI
SICI code
0018-019X(2001)84:6<1347:HOTOSO>2.0.ZU;2-P
Abstract
RNA is adsorbed strongly on suspensions of many moderately soluble organic solids. In some cases, the hydrolysis of tRNA(Phe) is greatly accelerated b y adsorption, and the major sites of hydrolysis are changed from those that are important in homogeneous solution. Here we show that the hydrolysis is greatly accelerated by suspensions of aspartic acid and beta -glutamic aci d but not by suspensions of alpha -glutamic acid. asparagine, or glutamine.