Sm. Huang et al., Extreme hypergastrinemia caused by atrophic gastritis and Helicobacter pylori infection - A case report, HEP-GASTRO, 48(40), 2001, pp. 1215-1216
We present a case with extremely high serum gastrin induced by atrophic gas
tritis and Helicobacter pylori infection. The patient, a 95-year-old male,
was diagnosed with idiopathic chronic diarrhea. During diagnostic work-up,
his fasting serum gastrin was up to 2078pg/mL. The secretin test was negati
ve for gastrinoma. Octreotide scan showed no suspicious lesion except for d
iffuse faint uptake over the gastric antrum on the 48-hour-delay film. Gast
ric acidity test revealed achlorhydria. On histology examination, atrophic
gastritis with Helicobacter pylori infection was found in the gastric body,
but the antral mucus was normal with a slight increase in gastrin-secretin
g cells. To our knowledge, such extremely high serum gastrin induced by atr
ophic gastritis and Helicobacter pylori infection has never been reported b
efore.