EVIDENCE FOR PREECLAMPSIA IN A BABOON PREGNANCY WITH TWINS

A primigravid baboon pregnant with twins developed a spontaneous clini cal syndrome with characteristics similar to human preeclampsia. Evide nce of preeclampsia included increased mean blood pressure, the occurr ence of proteinuria, a decrease in platelet count, and renal endotheli osis (i.e., glomerular capillary subendothelial deposits, mesangial fi brin deposition and expansion, and double-contouring of the glomerular basement membrane with endothelial cell swelling and lysis). These le sions occurred spontaneously and resolved postpartum.