The application to clinical medicine of evidence-based clinical guidelines
is an increasingly international policy prescription, yet research on how s
uch guidelines might be implemented has tended to focus on change initiativ
es without seeking to understand change processes. This paper reports an em
pirical study of guideline implementation in UK general practice. Most GPs
welcome guidelines as a means of improving care, though have reservations a
bout their authority, relevance and effect on professional autonomy. 'Clan'
organizational culture predominates and general practices do not generally
have well - functioning internal arrangements for the management of clinic
al evidence and related information. We found no coherent relationships bet
ween these variables and practices' actual uptake of guidelines. Copyright
(C) 2001 John Wiley & Sons, Ltd.