Citation
C. Burger et al., Cross-linking chitosan-Fe(III), an oral phosphate binder: studies in vitroand in vivo, INT J PHARM, 223(1-2), 2001, pp. 29-33
Citations number
22
Categorie Soggetti
Pharmacology & Toxicology
Journal title
INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN journal
03785173
→ ACNP
Volume
223
Issue
1-2
Year of publication
2001
Pages
29 - 33
Database
ISI
SICI code
0378-5173(20010731)223:1-2<29:CCAOPB>2.0.ZU;2-H
Abstract
The objective was to evaluate the in vitro and in vivo phosphate binding pr
operties of cross-linked chitosan iron (III) (CH-Fe(III)-CL), a potential o
ral phosphate binder for treating hyperphosphatemia. At equilibrium, the in
vitro phosphate binding of CH-Fe(III)-CL was 23.6 mg g(-1) for simulated g
astrointestinal conditions. In hyperphosphatemic rats, CH-Fe(III)-CL was si
milar to iron sulfate in reducing serum phosphate by about 35%. (C) 2001 El
sevier Science B.V. All rights reserved.