Patients with dementia with Lewy bodies (DLB) have progressive deficits in
cognition, parkinsonism, and neuropsychiatric symptoms. Cholinesterase inhi
bitors have been used to ameliorate cognitive decline and neuropsychiatric
symptoms in short-term trials. In this study, patients with DLB were treate
d with rivastigmine up to 96 weeks. Improvement from baseline was seen in c
ognitive function as measured by the Mini-Mental State Examination (MMSE),
and neuropsychiatric symptoms as measured by the Neuropsychiatric Inventory
(NPI) over the first 24 weeks of treatment. By 96 weeks, neither the MMSE
scores nor the NPI scores were significantly worse than at baseline.