This article explores the cultural context of the new transdisciplinary fie
ld of molecular biology in the three countries that did the most to establi
sh it - Great Britain, the United States, and France. It inquires into thre
e aspects of each of these national cultures that may help explain its prom
inence as a cradle of molecular biology: (1) Political culture, especially
science policy, as an area that impinges most directly on the production of
scientific knowledge; (2) Intellectual culture, especially the role of sci
entists in the national tradition of "public intellectuals"; (3) Institutio
nal culture, or the social and material cultures prevailing in major labora
tories and research institutes. The article also examines the convergence o
f these three national traditions in the 1960s, due to the rise of internat
ional collaborations and international institutions. It is suggested that t
his trend will continue in the twenty-first century, as molecular biology i
ncreasingly faces the challenge of a new cultural context - transnational g
lobalisation and multiculturalism.