In vitro comparison of the antimycotic activity of a miconazole-HP-beta-cyclodextrin solution with a miconazole surfactant solution

The antimycotic activity of a new parenteral solution containing miconazole was compared with that of a marketed solution (Daktarin IV solution). This solution has been withdrawn from the Belgian market, probably because of t oxic effects related to the presence of polyoxyl 35 castor oil. We propose a new formulation containing miconazole (10 mg/mL) (like the marketed solut ion), in combination with hydroxypropyl-beta -cyclodextrin and lactic acid. The MICs of these two solutions were determined by a broth microdilution m ethod (based on NCCLS guidelines) for 67 yeasts and 50 filamentous fungi is olates. This study shows that the MICs obtained with these two solutions ar e not significantly different.