The in vitro activity of HMR 3562, a new 2-fluoro-ketolide drug, was invest
igated against 95 enterococci, including 36 vancomycin-resistant strains. H
MR 3562 inhibited 90% of enterococci susceptible or resistant to erythromyc
in A at 0.005 and 0.6 mg/L, respectively. HMR 3562 was highly active in mur
ine peritonitis induced by five enterococci, irrespective of resistance phe
notype, displaying effective doses in the range 3.4-21.8 mg/kg. The results
demonstrate the potential of HMR 3562 in the treatment of infections cause
d by multiresistant enterococci.