Molecular properties and physiological roles of ion channels in the immunesystem

Citation
Md. Cahalan et al., Molecular properties and physiological roles of ion channels in the immunesystem, J CLIN IMM, 21(4), 2001, pp. 235-252
Citations number
167
Categorie Soggetti
Immunology
Journal title
JOURNAL OF CLINICAL IMMUNOLOGY
ISSN journal
02719142 → ACNP
Volume
21
Issue
4
Year of publication
2001
Pages
235 - 252
Database
ISI
SICI code
0271-9142(200107)21:4<235:MPAPRO>2.0.ZU;2-6
Abstract
The discovery of a diverse and unique set of ion channels in T lymphocytes has led to a rapidly growing body of knowledge about their functional roles in the immune system. Here we review the biophysical and molecular charact erization of K+, Ca2+, and Cl- channels in T lymphocytes. Potent and specif ic blockers, especially of K+ channels, have provided molecular tools to el ucidate the involvement of voltage- and calcium-activated potassium channel s in T-cell activation and cell-volume regulation. Their unique and differe ntial expression makes lymphocyte K+ channels excellent pharmaceutical targ ets for modulating immune system function. This review surveys recent progr ess at the biophysical, molecular, and functional roles of the ion channels found in T lymphocytes.