Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis clinical isolates from India

Authors
Mani, C Selvakumar, N Narayanan, S Narayanan, PR
Citation
C. Mani et al., Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis clinical isolates from India, J CLIN MICR, 39(8), 2001, pp. 2987-2990
Citations number
24
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Microbiology
Journal title
JOURNAL OF CLINICAL MICROBIOLOGY
ISSN journal
00951137 → ACNP
Volume
39
Issue
8
Year of publication
2001
Pages
2987 - 2990
Database
ISI
SICI code
0095-1137(200108)39:8<2987:MITRGO>2.0.ZU;2-L
Abstract
Mutations in the 81-bp rifampin resistance-determining region (RRDR) of the rpoB gene were analyzed by DNA sequencing of 50 Mycobacterium tuberculosis clinical isolates (44 resistant and 6 sensitive) from various parts of Ind ia. Fifty-three mutations of 18 different kinds, 17 point mutations and one deletion, were observed in 43 of 44 resistant isolates. Three novel mutati ons and three new alleles within the RRDR, along with two novel mutations o utside the RRDR, are reported in this study.